The benefits of enzyme catalysts in the production of biodiesel have been known however, their adoption on a commercial scale has not been economically feasible due to their sensitivity to methanol and high temperature. Cheaper aqueous methanol or ethanol can be used with the same rate of conversion. The use of aqueous methanol is an added value and allows the process to be cheaper. In the enzymatic process, there is no soap & no caustic formation. Less than tenth of the energy consumed in the chemical process (one kWh per cubic meter) is required in the proposed enzymatic process. The enzyme provides plant flexibility and it allows expanding the feedstock selection to multi-functional plants working with cheaper feedstocks. True economic benefit of enzymes comes in their ability to handle a variety of inexpensive and high FFAs feedstocks such as brown grease, acid oils, used cooking oil, animal fat, etc.